William J McKenna Selected Research

Desmoplakins (Desmoplakin)

12/2017	Desmoplakin missense and non-missense mutations in arrhythmogenic right ventricular cardiomyopathy: Genotype-phenotype correlation.
8/2012	Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study.
8/2010	Prevalence of desmosomal protein gene mutations in patients with dilated cardiomyopathy.
5/2009	Unique epidermolytic bullous dermatosis with associated lethal cardiomyopathy related to novel desmoplakin mutations.
11/2006	Arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2.
8/2005	Novel mutation in desmoplakin causes arrhythmogenic left ventricular cardiomyopathy.
8/2005	Desmoplakin disease in arrhythmogenic right ventricular cardiomyopathy: early genotype-phenotype studies.

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William J McKenna Research Topics

Disease

34	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2021 - 01/2002
22	Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy) 01/2021 - 03/2004
15	Cardiomyopathies (Cardiomyopathy) 01/2022 - 08/2005
15	Heart Failure 01/2019 - 08/2002
13	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2021 - 08/2002
8	Cardiac Sudden Death (Sudden Cardiac Arrest) 11/2021 - 09/2010
7	Fibrosis (Cirrhosis) 12/2018 - 02/2002
6	Ventricular Tachycardia 01/2020 - 09/2010
6	Sudden Death 08/2013 - 12/2002
5	Hypertrophy 11/2015 - 05/2003
4	Myocarditis (Carditis) 01/2022 - 08/2002
4	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2016 - 12/2003
3	Ventricular Fibrillation 01/2019 - 09/2010
3	Heart Diseases (Heart Disease) 01/2018 - 01/2006
3	Cardiac Arrhythmias (Arrythmia) 01/2018 - 12/2008
3	Shock 01/2016 - 08/2013
3	Restrictive Cardiomyopathy 05/2012 - 01/2003
3	Familial Hypertrophic Cardiomyopathy (Cardiomyopathy, Familial Hypertrophic) 11/2011 - 01/2002
3	Naxos disease 11/2007 - 05/2004
2	Left Ventricular Dysfunction 01/2020 - 08/2010
2	Inflammation (Inflammations) 01/2020 - 10/2011
2	Ventricular Premature Complexes (Premature Ventricular Contraction) 01/2019 - 07/2017
2	Muscular Diseases (Myopathy) 12/2013 - 03/2005
2	Long QT Syndrome 10/2013 - 01/2007
2	Cardiovascular Diseases (Cardiovascular Disease) 08/2012 - 07/2005
2	Cardiomegaly (Heart Hypertrophy) 03/2005 - 02/2002
2	Wolff-Parkinson-White Syndrome (Wolf-Parkinson-White Syndrome) 03/2005 - 02/2002
1	Aortic Valve Stenosis (Aortic Stenosis) 12/2018
1	Disease Progression 01/2018
1	Cicatrix (Scar) 07/2017
1	Deafness (Deaf Mutism) 12/2013
1	Glycogen Storage Disease Type IIb 12/2013
1	Brain Diseases (Brain Disorder) 12/2013
1	Mitochondrial Diseases (Mitochondrial Disease) 12/2013
1	Retinitis 12/2013
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 12/2013
1	Acidosis 12/2013
1	Cognitive Dysfunction 12/2013
1	Lactic Acidosis 12/2013
1	Sudden Infant Death (SID) 10/2013
1	Noonan Syndrome (Female Pseudo-Turner Syndrome) 06/2012
1	Sarcoidosis (Schaumann Disease) 10/2011
1	Familial Sudden Death 09/2010

Drug/Important Bio-Agent (IBA)

26	Proteins (Proteins, Gene)FDA Link 12/2018 - 01/2002
9	GadoliniumIBA 01/2020 - 05/2003
8	gamma Catenin (Plakoglobin)IBA 10/2011 - 05/2004
7	Desmoplakins (Desmoplakin)IBA 12/2017 - 08/2005
6	Troponin IIBA 03/2013 - 01/2002
5	Troponin T (Troponin T1)IBA 01/2019 - 01/2002
5	Cardiac MyosinsIBA 04/2012 - 01/2002
3	Biological ProductsIBA 01/2020 - 02/2012
3	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2019 - 08/2006
3	Lamin Type A (Lamin A)IBA 01/2018 - 12/2010
3	Carrier Proteins (Binding Protein)IBA 04/2012 - 01/2002
3	Myosins (Myosin)IBA 11/2011 - 08/2002
2	FilaminsIBA 11/2021 - 01/2020
2	myosin-binding protein CIBA 06/2016 - 08/2008
2	Biomarkers (Surrogate Marker)IBA 07/2015 - 10/2012
2	Connexin 43 (Connexin43)IBA 08/2012 - 05/2004
2	Myosin Heavy Chains (Myosin Heavy Chain)IBA 11/2011 - 08/2008
2	Cadherins (E-Cadherin)IBA 10/2010 - 11/2006
2	Desmoglein 2IBA 10/2010 - 11/2006
2	Troponin CIBA 03/2007 - 11/2004
2	AutoantibodiesIBA 01/2007 - 08/2002
2	DNA (Deoxyribonucleic Acid)IBA 01/2007 - 03/2004
2	Adenylate KinaseIBA 03/2005 - 02/2002
2	Ventricular MyosinsIBA 03/2005 - 08/2002
1	ConnectinIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2020
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2019
1	Anti-Arrhythmia AgentsIBA 01/2019
1	Trimetazidine (Vastarel)IBA 01/2019
1	LumicanIBA 12/2018
1	PlectinIBA 01/2018
1	LaminsIBA 01/2018
1	Carbon DioxideIBA 11/2015
1	Creatine Kinase (Creatine Phosphokinase)IBA 12/2013
1	Caveolin 3IBA 10/2013
1	pro-brain natriuretic peptide (1-76)IBA 08/2013
1	phospholambanIBA 04/2013
1	TroponinIBA 03/2013
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 03/2013
1	insulin receptor-related receptor (IRR)IBA 08/2012
1	Mitogen-Activated Protein KinasesIBA 06/2012
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2011
1	Interleukin-6 (Interleukin 6)IBA 10/2011
1	CateninsIBA 10/2011
1	CytokinesIBA 10/2011
1	InterleukinsIBA 10/2011
1	Peptides (Polypeptides)IBA 07/2009

Therapy/Procedure

17	Therapeutics 01/2022 - 12/2002
11	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2018 - 02/2005
8	Heart Transplantation (Grafting, Heart) 11/2021 - 08/2002
2	Transplantation 11/2015 - 07/2004
2	Cardiac Resynchronization Therapy 05/2008 - 02/2003
2	Cardiac Rehabilitation 07/2005 - 03/2005
1	Heart-Assist Devices 01/2019
1	Drug Therapy (Chemotherapy) 01/2019
1	Defibrillators (Defibrillator) 01/2016